Histological Assessment of Vaginal Wall at Different Stages of Pelvic Organ Prolapse
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چکیده
Hypothesis / aims of study Collagen is ubiquitous in the human body and it is the main component of connective tissue. Several different types of collagen have been identified and is known that it is strongly represented in the vaginal wall and endopelvic fascia. Therefore collagen is the main component of the pelvic supporting structures and Pelvic Organ Prolapse (POP) is the clinical manifestation of a muscular and connective tissue damage while pelvic floor reconstructive surgery mostly uses damaged fascial structures for primary repair of POP. The role of collagen in the physiopathology of POP has been studied with conflicting results, being difficult to distinguish the cause from the effect and to standardize the samples (1). In this study it has been evaluated the microscopic morphology of the anterior and posterior vaginal wall of patients affected by different stages of POP.
منابع مشابه
Biomechanical properties and associated collagen composition in vaginal tissue of women with pelvic organ prolapse.
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Background & Aim: Pelvic organ prolapse which is defined as displacement of bladder, uterus or rectum from their normal position downward is very common in elder women and causes significant morbidity. It is necessary to have a standard staging to investigate this problem, factors influencing it, and the effect of different therapeutic procedures on the course of disease. The aim of this st...
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